FBXL19 is a substrate-recognition component of SCF-type E3 ubiquitin ligase complexes that regulates multiple cellular processes through protein degradation and transcriptional control 12. The protein mediates ubiquitination and degradation of key signaling molecules including RHOA in an ERK2-dependent manner 3, and RAC1/RAC3, thereby suppressing TGFB1-induced cell migration 41. Beyond cytoplasmic functions, FBXL19 localizes to the nucleus where it binds unmethylated CpG dinucleotides and recruits CDK-mediator complexes to chr16, facilitating developmental gene activation 5. FBXL19 is associated with psoriasis and psoriatic arthritis susceptibility through genome-wide association studies, implicating roles in innate immune and nuclear factor-κB signaling pathways 67. Recent evidence demonstrates that FBXL19 genetic variants correlate with Streptococcus skin colonization and psoriasis severity, likely through IL-33/IL1RL1 axis regulation 8. Additionally, endothelial FBXL19 overexpression protects cardiac tissue from influenza A infection by enhancing interferon-mediated antiviral responses and reducing cellular senescence 9. The antisense lncRNA FBXL19-AS1 functions as an oncogene in multiple cancers via miRNA-mediated pathways 1011.