FBXO47 is an F-box protein that functions as a component of the SCF (SKP1-Cullin-F-box) ubiquitin E3 ligase complex, recognizing phosphorylated substrate proteins and promoting their polyubiquitination and proteasomal degradation 1. Originally identified in a region deleted in papillary renal cell carcinoma and preferentially expressed in normal tissues, FBXO47 exhibits tumor-suppressor properties 2. In cancer contexts, FBXO47 expression is downregulated: the GABPB1-AS1/miR-566/FBXO47 axis suppresses non-small cell lung cancer progression 3, while tRF-3019a targets FBXO47 to enhance gastric cancer proliferation and invasion 4. FBXO47's primary biological role is meiosis-specific, where it functions at centromeres and telomeres. During early meiosis, FBXO47 interacts with SKP1 and HORMAD1, targeting HORMAD1 for degradation to prevent aberrant DNA double-strand break accumulation 1. At centromeres, FBXO47 regulates centromere pairing and stabilizes SKP1 to facilitate proper synaptonemal complex formation 5. FBXO47 also stabilizes TRF2 in the telomeric shelterin complex, enabling proper telomere-nuclear envelope attachment during meiosis 6. Fbxo47 knockout mice exhibit male infertility due to meiotic arrest. FBXO47 variants show no significant association with multiple system atrophy in Asian populations 7.