FBXO8 (F-box protein 8) functions as a tumor suppressor protein that regulates cellular processes through its dual roles in ubiquitin-mediated protein degradation and vesicle trafficking. As a component of SCF E3 ubiquitin ligase complexes, FBXO8 targets oncoproteins including c-MYC, HIF-1α, CDK4, and GSTP1 for proteasomal degradation 12. The protein contains both F-box and Sec7 domains, with the latter mediating guanine-nucleotide exchange activity on ARF proteins and promoting vesicle-mediated transport 3. FBXO8 expression is significantly downregulated across multiple cancer types including hepatocellular carcinoma, colorectal cancer, gastric cancer, breast cancer, and acute lymphoblastic leukemia, where low expression correlates with poor prognosis, increased metastasis, and shorter survival 4567. Mechanistically, FBXO8 suppresses cell proliferation, invasion, and metastasis by degrading key oncoproteins and maintaining metastatic dormancy 1. The protein participates in a negative feedback loop with c-MYC, where c-MYC binding inhibits FBXO8 function in cell invasion through ARF6 pathway modulation 3. These findings establish FBXO8 as both a prognostic biomarker and potential therapeutic target across various malignancies.