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10 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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FDPS
farnesyl diphosphate synthase
Chromosome 1 · 1q22
NCBI Gene: 2224Ensembl: ENSG00000160752.15HGNC: HGNC:3631UniProt: A0A087X090
123PubMed Papers
21Diseases
11Drugs
5Pathogenic Variants
CLINICAL
FDA Approved TargetOMIM Disease Gene
DATA QUALITY
✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
RNA bindingprotein bindingdimethylallyltranstransferase activityfarnesyl diphosphate biosynthetic processporokeratosis 9, multiple typesosteoporosispostmenopausal osteoporosismultiple myeloma
✦AI Summary

I cannot provide a gene function summary for FDPS based on the provided abstracts. The PubMed abstracts supplied concern dental prosthetics and fixed dental prostheses (FDPs) outcomes, which are entirely unrelated to FDPS (farnesyl diphosphate synthase) gene function. None of the abstracts 12345678 contain information about farnesyl diphosphate synthase, isoprenoid biosynthesis, protein prenylation, cholesterol synthesis, or porokeratosis. To provide an accurate, citation-supported summary of FDPS gene function and its role in isoprenoid metabolism and disease, relevant molecular and clinical literature would be required.

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsⓘ21
porokeratosis 9, multiple typesOpen Targets
0.64Moderate
osteoporosisOpen Targets
0.61Moderate
postmenopausal osteoporosisOpen Targets
0.61Moderate
multiple myelomaOpen Targets
0.60Moderate
osteitis deformansOpen Targets
0.60Moderate
prostate cancerOpen Targets
0.59Moderate
metastasisOpen Targets
0.59Moderate
prostate carcinomaOpen Targets
0.59Moderate
bone fractureOpen Targets
0.58Moderate
HypercalcemiaOpen Targets
0.56Moderate
bone diseaseOpen Targets
0.56Moderate
breast neoplasmOpen Targets
0.55Moderate
Paget diseaseOpen Targets
0.55Moderate
bone metastasisOpen Targets
0.54Moderate
breast cancerOpen Targets
0.54Moderate
cancerOpen Targets
0.53Moderate
disseminated superficial actinic porokeratosisOpen Targets
0.50Moderate
neurodegenerative diseaseOpen Targets
0.40Moderate
OsteopeniaOpen Targets
0.39Weak
breast diseaseOpen Targets
0.37Weak
Porokeratosis 9, multiple typesUniProt
Pathogenic Variants5
NM_002004.4(FDPS):c.684+2T>GLikely pathogenic
not provided
★☆☆☆2019
NC_000001.11:g.(?_155282411)_(155323834_?)delPathogenic
not provided
★☆☆☆2019
NM_002004.4(FDPS):c.536G>A (p.Arg179Gln)Pathogenic
Porokeratosis 9, multiple types
☆☆☆☆2015→ Residue 179
NM_002004.4(FDPS):c.481-1776_847-143delPathogenic
Porokeratosis 9, multiple types
☆☆☆☆2015
NM_002004.4(FDPS):c.684+1G>APathogenic
Porokeratosis 9, multiple types
☆☆☆☆2015
View on ClinVar ↗
Drug Targets11
ALENDRONATE SODIUMApproved
Farnesyl diphosphate synthase inhibitor
osteoporosis
ALENDRONIC ACIDApproved
Farnesyl diphosphate synthase inhibitor
osteoporosis
IBANDRONATE SODIUMApproved
Farnesyl diphosphate synthase inhibitor
postmenopausal osteoporosis
IBANDRONIC ACIDApproved
Farnesyl diphosphate synthase inhibitor
osteoporosis
MINODRONIC ACIDApproved
Farnesyl diphosphate synthase inhibitor
osteoporosis
PAMIDRONATE DISODIUMApproved
Farnesyl diphosphate synthase inhibitor
PAMIDRONIC ACIDApproved
Farnesyl diphosphate synthase inhibitor
Hypercalcemia
RISEDRONATE SODIUMApproved
Farnesyl diphosphate synthase inhibitor
osteoporosis
RISEDRONIC ACIDApproved
Farnesyl diphosphate synthase inhibitor
Paget disease
ZOLEDRONIC ACIDApproved
Farnesyl diphosphate synthase inhibitor
metastasis
ZOLEDRONIC ACID ANHYDROUSApproved
Farnesyl diphosphate synthase inhibitor
Hypercalcemia
Related Genes
FNTBProtein interaction95%RSAD2Protein interaction95%DHDDSProtein interaction95%PDSS1Protein interaction94%HMGCS2Protein interaction92%PDSS2Protein interaction92%
Tissue Expression6 tissues
Liver
100%
Brain
83%
Lung
69%
Heart
43%
Bone Marrow
41%
Ovary
33%
Gene Interaction Network
Click a node to explore
FDPSFNTBRSAD2DHDDSPDSS1HMGCS2PDSS2
PROTEIN STRUCTURE
Preparing viewer…
PDB5CG5 · 1.40 Å · Other
View on RCSB ↗
Constraintⓘ
LOEUFⓘ
0.74LoF Tolerant
pLIⓘ
0.00Tolerant
Observed/Expected LoF0.54 [0.40–0.74]
RankingsWhere FDPS stands among ~20K protein-coding genes
  • #3,820of 20,598
    Most Researched123 · top quartile
  • #146of 1,025
    FDA-Approved Drug Targets11 · top quartile
  • #3,513of 5,498
    Most Pathogenic Variants5
  • #5,866of 17,882
    Most Constrained (LOEUF)0.74
Genes detectedFDPS
Sources retrieved10 papers
Response time—
📄 Sources
10▼
1
A systematic review of the survival and complication rates of zirconia-ceramic and metal-ceramic multiple-unit fixed dental prostheses.
PMID: 30328185
Clin Oral Implants Res · 2018
1.00
2
Comparison of survival and complication rates of tooth-supported fixed dental prostheses (FDPs) and implant-supported FDPs and single crowns (SCs).
PMID: 17594374
Clin Oral Implants Res · 2007
0.90
3
All-ceramic or metal-ceramic tooth-supported fixed dental prostheses (FDPs)? A systematic review of the survival and complication rates. Part II: Multiple-unit FDPs.
PMID: 25935732
Dent Mater · 2015
0.80
4
All-ceramic or metal-ceramic tooth-supported fixed dental prostheses (FDPs)? A systematic review of the survival and complication rates. Part I: Single crowns (SCs).
PMID: 25842099
Dent Mater · 2015
0.70
5
Efficacy and risks of removable partial prosthesis in periodontitis patients: A systematic review.
PMID: 34761421
J Clin Periodontol · 2022
0.60