FGFBP1 is an extracellular carrier protein that releases fibroblast growth factors (FGFs) from extracellular matrix storage, thereby enhancing FGF mitogenic signaling 1. Beyond its canonical FGF-binding function, FGFBP1 exhibits novel growth factor-like activity in keratinocytes, where it maintains cell morphology and regulates F-actin rearrangement in an HAI-1-dependent manner 2. In cancer biology, FGFBP1 promotes triple-negative breast cancer progression through the KLK10-AKT signaling axis 3, while in colorectal cancer liver metastasis, hypoxia-induced FGFBP1 upregulation drives bevacizumab resistance via paracrine FGF2/FGFR1/ERK1/2 signaling in hepatic stellate cells 1. FGFBP1 also mediates muscle-liver crosstalk during acute liver injury, where it regulates hepatic FGF5 signaling through liquid-liquid phase separation mechanisms to promote liver regeneration 4. Clinically, FGFBP1 serves as a prognostic biomarker in esophageal squamous cell carcinoma, bladder cancer BCG response prediction, and endothelial dysfunction 567. Genetic variation in FGFBP1 influences bone mineral density through testosterone-responsive promoter polymorphisms 8.