FKBP2 encodes a 13-kDa FK506-binding protein that functions as a peptidyl-prolyl cis-trans isomerase (PPIase) localized to the endoplasmic reticulum lumen 12. As a molecular chaperone, FKBP2 accelerates protein folding by catalyzing the cis-trans isomerization of proline imidic peptide bonds in oligopeptides, playing a crucial role in ER protein folding processes 1. The protein demonstrates anti-apoptotic properties, as evidenced by its ability to inhibit Bax-induced apoptosis in yeast models 1. FKBP2 is mapped to chromosome 11.1-q13.3 and was initially investigated as a candidate tumor suppressor gene for multiple endocrine neoplasia type 1 (MEN1), though this association was ultimately excluded 23. Recent genome-wide association studies have identified FKBP2 as a risk gene for psychiatric disorders, including bipolar disorder, schizophrenia, and depression 456. Additionally, FKBP2 has been implicated in glioblastoma prognosis as part of a hypoxia-related gene signature 78. The protein's expression is regulated by hypoxic conditions and may contribute to tissue-specific responses to oxygen deprivation 8.