FOXK1 is a forkhead transcription factor that functions as a master regulator of metabolic reprogramming and cellular proliferation across multiple tissues. As a sequence-specific DNA-binding transcription factor, FOXK1 recognizes forkhead motifs and acts contextually as an activator or repressor 1. Its primary metabolic role involves coordinating the shift toward aerobic glycolysis by upregulating glycolytic enzymes (hexokinase-2, phosphofructokinase, pyruvate kinase, lactate dehydrogenase) while suppressing pyruvate oxidation through pyruvate dehydrogenase kinase activation 2. In response to insulin signaling, FOXK1 translocates to the nucleus via the Akt-mTOR pathway to regulate cell cycle progression and lipid metabolism 3. Beyond metabolism, FOXK1 promotes cardiomyocyte proliferation by activating CCNB1/CDK1 and enhancing glycolysis-dependent energy production 4, and stimulates osteoblast differentiation and bone formation through aerobic glycolysis induction 5. FOXK1 also drives glycolysis in renal tubular epithelial cells during chr7 kidney disease progression through liquid-liquid phase separation-mediated transcriptional activity 6. Dysregulation of FOXK1 contributes to disease pathogenesis: elevated FOXK1 in fibroblast-like synoviocytes promotes rheumatoid arthritis, while propionate-mediated FOXK1 destabilization ameliorates disease 7. These findings establish FOXK1 as a therapeutic target for metabolic and degenerative diseases.