FOXP2 is a transcriptional repressor and DNA-binding transcription factor that plays pleiotropic roles in development and neural function. Structurally, FOXP2 contains a forkhead box DNA-binding domain and glutamine-rich regions; its DNA binding provides a solubilizing effect that prevents pathological protein aggregation 1. The gene is primarily known for its role in speech and language development, being the first gene implicated in a speech-language disorder 2. In the brain, human FOXP2 increases synaptic plasticity and dendrite connectivity in the basal ganglia, which regulate language, cognition, and motor control 3. FOXP2 shows human-specific upregulation in specific neuronal subtypes of the posterior cingulate cortex 4, and is implicated in thalamic development where its overexpression mediates axon overgrowth in a 22q11.2 microdeletion model of psychiatric disorders 5. Beyond neurological functions, FOXP2 plays developmental roles in cardiac tissue, where it is implicated in the pacemaker phenotype 6. Recently, FOXP2 was identified as a promoter of kidney fibrosis through epithelial-to-mesenchymal transition and cell cycle arrest in tubular cells 7. Mutations in FOXP2 are associated with congenital disorders, highlighting its importance in human development 8.