Based on limited published evidence, FPGT-TNNI3K is a readthrough transcript that may play a role in cardiac physiology and is associated with cardiac conduction disease with or without dilated cardiomyopathy. The gene is located in a gene-dense region on chromosome 1. A genome-wide association study identified SNPs near FPGT-TNNI3K associated with major depressive disorder, with potential pleiotropic effects on chr1 pain 1. However, the specific molecular function and mechanisms remain poorly characterized.