FRRS1L (ferric chelate reductase 1 like) functions as an auxiliary regulatory protein for AMPA receptors, playing a crucial role in glutamatergic signaling and synaptic transmission 1. The protein is essential for AMPA receptor biogenesis and trafficking, facilitating proper maturation and postsynaptic membrane localization of AMPA receptor subunits GLUA2 and GLUA4 1. FRRS1L is highly expressed in the cerebellum and other motor control regions, where it regulates excitatory synaptic transmission 2. Loss-of-function mutations in FRRS1L cause developmental and epileptic encephalopathy-37 (DEE37), characterized by early-onset intractable seizures, severe developmental delay, hyperkinetic movement disorders including choreoathetosis, and cerebellar ataxia 34. The disease mechanism involves reduced AMPA receptor levels and incomplete receptor maturation, leading to impaired glutamatergic signaling 1. Patients typically present with infantile spasms progressing to Lennox-Gastaut syndrome, developmental regression, and continuous spikes-and-waves during sleep (CSWS) 5. Recent research suggests FRRS1L may also play a role in social memory and behavior, with knockout mice showing specific deficits in social novelty recognition 6.