FUT6 encodes an α(1,3)-fucosyltransferase enzyme that catalyzes the addition of fucose residues to glycoproteins and glycolipids, playing important roles in glycan biosynthesis 1. The enzyme is involved in protein O-linked and N-linked glycosylation processes and functions within the Golgi apparatus 1. FUT6 is located on chromosome 19.3 as part of a gene cluster with FUT3 and FUT5, sharing over 85% homology with these related fucosyltransferases 2. The gene exhibits significant genetic polymorphism, with deficient alleles having low incidence and being found mainly around the Indian Ocean region 1. FUT6 polymorphisms are associated with Helicobacter pylori infection susceptibility in Han Chinese populations 3. In cancer biology, FUT6 appears to function as a tumor suppressor, with reduced expression promoting cell migration, invasion, and proliferation in breast cancer 4 and head and neck squamous cell carcinoma 5. The protein regulates cancer cell behavior through the EGFR/ERK/STAT signaling pathway and epithelial-mesenchymal transition 5. Additionally, FUT6 genetic variants influence human milk oligosaccharide composition, affecting infant nutrition 6.