FXR2 is an mRNA-binding protein and member of the Fragile X protein family that regulates translation and mRNA stability through binding to AU-rich elements (AREs) in 3'-UTRs 1. The protein functions as a regulator of adult hippocampal neurogenesis by modulating translation and stability of target mRNAs, including NOG mRNA in the dentate gyrus, thereby controlling neuronal development [UniProt annotation supported by GO terms]. FXR2 undergoes liquid-liquid phase separation upon binding ARE-containing mRNAs, enabling formation of membraneless compartments that regulate mRNA storage, translation, and stability. The protein is coexpressed with FMR1 and FXR1 in differentiated neurons throughout the brain 2, and exhibits tissue-specific expression patterns during development 3. FXR2 interacts with other Fragile X family members and associates with ribosomal machinery 2. Recent evidence links FXR2 dysfunction to amyotrophic lateral sclerosis pathogenesis, with loss of FXR2 expression implicated in disease progression 1. Additionally, FXR2 participates in trained immunity against tuberculosis by stabilizing CLOCK mRNA in collaboration with the lncRNA TRCR1, enhancing innate immune memory 4. FXR2 expression is transcriptionally regulated by NF-Y, AP2, Nrf1, and Sp1 5.