G3BP2 is a scaffold protein that plays essential roles in cytoplasmic stress granule (SG) formation and cellular signaling pathways 12. G3BP2 functions as a core component of stress granules, which are membraneless compartments that store mRNAs and stalled translation complexes during cellular stress 34. The protein acts as an RNA condenser, promoting intermolecular RNA-RNA interactions that stabilize RNA condensates and enable stress granule persistence 3. Beyond stress granules, G3BP2 localizes to the cytoplasmic surface of lysosomes where it anchors the tuberous sclerosis complex (TSC) and suppresses mTORC1 signaling in response to amino acids and insulin 5. G3BP2 also mediates PKR antiviral immunity through stress granule-dependent mechanisms, with deficiencies in SG assembly components leading to impaired PKR activation and increased viral susceptibility 4. Clinically, G3BP2 dysfunction is associated with neurodevelopmental disorders, with de novo variants disrupting SG formation and contributing to intellectual disability and behavioral issues 2. The protein is also implicated in cardiac hypertrophy through interactions with pathological long non-coding RNAs that activate NF-κB signaling cascades 6.