2 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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13PubMed Papers
0Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
protein binding
Based on limited published evidence, GAGE5 encodes a cancer-testis antigen that functions as a tumor-associated protein. According to GO annotations, GAGE5 possesses protein binding capability. GAGE5 is expressed in various human cancers including rhabdomyosarcoma (16% of cases) 1 and is overexpressed in paclitaxel/doxorubicin-resistant cancer cell lines 2. As a cancer-testis antigen with restricted normal tissue expression (spermatogonia and placenta), GAGE5 represents a potential immunotherapy target for cancer treatment 1.
1
GAGE5 is expressed in 16% of pediatric rhabdomyosarcomas and represents a tumor-associated antigen for potential immunotherapy
PMID: 113916262
GAGE5 is overexpressed in paclitaxel/doxorubicin-resistant human cancer cell lines alongside other MAGE/GAGE family members
PMID: 12855658⚠Limited data available — This gene has 2 indexed publications. Summary and analysis may be incomplete.
No pathogenic variants reported on ClinVar for this gene.
No tissue expression data available for this gene.