GARRE1 — granule associated Rac and RHOG effector 1

6 sources retrieved · Most recent: April 2026 · Index updated 3 months ago

40PubMed Papers

#10,153 · top 52% of 19K genes

20Diseases

top 57%

0Drugs

0Pathogenic Variants

Experimental GO EvidenceSwiss-Prot Reviewed

protein bindingsmall GTPase bindingCCR4-NOT complex bindingRac protein signal transductionAbnormality of the skeletal systemalcohol drinkingintestinal obstructionattention deficit hyperactivity disorder

AI Summary

Based on limited published evidence, GARRE1 acts as an effector of RAC1 in small GTPase signaling 1. It associates with the CCR4-NOT complex, a major cellular mRNA deadenylase involved in bulk mRNA degradation, miRNA-mediated repression, and translational regulation 2. GARRE1 may participate in miRNA silencing machinery 2. Recent RNA-seq analysis suggests GARRE1 expression in pubertal mammary epithelial cells may provide protective effects for immune and DNA damage responses 3.

Sources cited

GARRE1 acts as an effector of RAC1 protein

PMID: 31871319

GARRE1 associates with CCR4-NOT complex involved in mRNA degradation, miRNA-mediated repression, and translational regulation; may play a role in miRNA silencing

PMID: 29395067

GARRE1 expression in pubertal mammary epithelial cells may provide protective effects for immune and DNA damage responses

PMID: 39599711

⚠Limited data available — This gene has 3 indexed publications. Summary and analysis may be incomplete.

Disease Associations20

Abnormality of the skeletal systemOpen Targets

0.32Weak

alcohol drinkingOpen Targets

0.29Weak

intestinal obstructionOpen Targets

0.21Weak

attention deficit hyperactivity disorderOpen Targets

0.09Suggestive

attention deficit-hyperactivity disorder 8Open Targets

0.07Suggestive

hereditary attention deficit-hyperactivity disorderOpen Targets

0.07Suggestive

intellectual disability, autosomal recessive 59Open Targets

0.07Suggestive

movement disorderOpen Targets

0.07Suggestive

schizophrenia 15Open Targets

0.07Suggestive

Phelan-McDermid syndromeOpen Targets

0.05Suggestive

autismOpen Targets

0.05Suggestive

Tourette syndromeOpen Targets

0.05Suggestive

corneal dystrophyOpen Targets

0.05Suggestive

X-linked non-syndromic intellectual disabilityOpen Targets

0.04Suggestive

intellectual disability, autosomal dominant 50Open Targets

0.04Suggestive

Potocki-Lupski syndromeOpen Targets

0.04Suggestive

FRAXE intellectual disabilityOpen Targets

0.04Suggestive

X-linked dominant intellectual disability - epilepsy syndromeOpen Targets

0.03Suggestive

intellectual developmental disorder, X-linked, syndromic, Pilorge typeOpen Targets

0.03Suggestive

Smith-Magenis syndromeOpen Targets

0.03Suggestive

Pathogenic Variants

No pathogenic variants reported on ClinVar for this gene.

Tissue Expression6 tissues

Heart

100%

Lung

93%

Ovary

71%

Liver

54%

Brain

53%

Bone Marrow

36%

Gene Interaction Network6 neighbors

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Structure2 PDB hits

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PDB8BUY · 1.60 Å · X-ray

View on RCSB

ConstraintgnomAD v4.1

LOEUFⓘ

0.58Moderately Constrained

pLIⓘ

0.00Tolerant

Observed/Expected LoF0.45 [0.35–0.58]

Rankings2 dim

Where GARRE1 stands among ~20K protein-coding genes

#10,176of 20,598
Most Researched40
#3,858of 17,882
Most Constrained (LOEUF)0.58 · top quartile