GDPGP1 (GDP-D-glucose phosphorylase 1) is a metabolic enzyme that catalyzes the phosphorolysis of GDP-D-glucose to GDP and D-glucose 1-phosphate, thereby regulating cellular GDP-D-glucose levels 1. The enzyme functions as a quality control factor in nucleoside diphosphate sugar metabolism, preventing accumulation of GDP-D-glucose that could lead to misincorporation of glucosyl residues into glycoconjugates 1. GDPGP1 is highly expressed in nervous and male reproductive tissues 1. Beyond metabolic regulation, GDPGP1 plays a critical role in neuronal stress resistance through glycogen metabolism. Stress conditions down-regulate GDPGP1 expression, and this down-regulation represents a maladaptive response; GDPGP1 knockdown in mouse neurons causes widespread cell death, while loss-of-function in C. elegans increases neurodegeneration and reduces stress survival 2. Conversely, GDPGP1 overexpression enhances neuronal survival under hypoxia and protects against neurodegeneration in tauopathy models by maintaining glycogen levels and glucose homeostasis 2. Clinically, GDPGP1 expression is associated with unfavorable outcomes in advanced epithelial ovarian cancer, identifying it as a prognostic biomarker for disease-specific survival 3.