GET1 (guided entry of tail-anchored proteins factor 1) is a membrane protein essential for post-translational insertion of tail-anchored (TA) proteins into the endoplasmic reticulum. As part of the GET complex, GET1 functions as a membrane receptor that works with its binding partner GET2/CAMLG to receive TA protein substrates delivered by the cytosolic GET3/TRC40 chaperone 1. Structurally, GET1 and GET2 form a conserved heterotetramer insertase complex containing an aqueous channel approximately 2.5 nm in diameter that mediates transmembrane domain insertion into the ER membrane 2. The GET1/GET2 complex exhibits conformational plasticity upon GET3 binding, inducing local lipid bilayer thinning near the hydrophilic insertion groove to facilitate substrate translocation 1. GET1 is evolutionarily related to the Oxa1/Alb3/YidC protein family and shares conserved architecture with other membrane protein biogenesis factors 3. Clinically, genetic variants in GET1 have been associated with non-suicidal self-injury (NSSI) susceptibility in genome-wide association studies, with increased hippocampal GET1 expression linked to elevated NSSI risk 4. Additionally, GET1 DNA methylation patterns differ in newborns conceived through assisted reproductive technologies 5, suggesting potential epigenetic sensitivity. Functional studies demonstrate GET1 homologs are critical for pathogenic fungal development, indicating broader relevance to organism physiology 6.