GFRA2 (GDNF family receptor alpha 2) is a glycosylphosphatidylinositol (GPI)-anchored cell surface receptor that functions as a co-receptor in neurotrophic signaling pathways 1. The protein mediates neurturin (NRTN)-induced signaling by forming complexes that activate downstream receptor tyrosine kinases, particularly RET 23. GFRA2 has nine coding exons with structural similarity to other GFRA family members and contains heparan sulfate-binding sites that facilitate signaling complex assembly 12. The receptor plays crucial roles in nervous system development, particularly in myenteric nerve plexus formation 1. GFRA2 also functions as a cardiac progenitor cell marker and mediates cardiomyocyte differentiation through RET-independent pathways 4. In disease contexts, GFRA2 serves as a genetic modifier in frontotemporal lobar degeneration with GRN mutations, where decreased GFRA2 expression is associated with increased disease risk 5. The receptor is also implicated in pancreatic cancer progression, where neurturin-GFRA2-RET signaling enhances glycolysis by phosphorylating hexokinase 2 3. Additionally, GFRA2 expression is upregulated in degenerative disc disease and may contribute to discogenic pain pathogenesis 6.