GHSR (growth hormone secretagogue receptor) is a G-protein-coupled receptor that serves as the specific receptor for ghrelin, a 28-amino acid acylated peptide hormone primarily produced in the stomach 1. Upon ghrelin binding, GHSR stimulates growth hormone release from the pituitary and regulates appetite and energy balance 1. The receptor is expressed throughout the brain, particularly in the hypothalamus, and mediates ghrelin's effects on feeding behavior and metabolic processes 23. GHSR exhibits unique ligand-independent constitutive activity, making it an attractive therapeutic target 4. The ghrelin-GHSR system demonstrates complex roles in disease states: it contributes to hyperglycemia and insulin resistance in type 2 diabetes 5, while paradoxically showing anti-inflammatory properties in rheumatoid arthritis through PI3K/AKT pathway modulation 6. The receptor also influences mental health disorders by affecting neurotransmitter systems including dopamine, GABA, and serotonin 2. Clinically, GHSR shows promise as a therapeutic target for obesity, with genetic or pharmacological blockade demonstrating protective effects against diet-induced obesity in a sexually dimorphic manner 4. The system's involvement in cancer progression and metabolic disorders highlights its significance in multiple pathophysiological processes 7.