GIMAP2 (GTPase, IMAP family member 2) is a lymphocyte survival regulator that functions through nucleotide-dependent oligomerization and membrane scaffolding. GIMAP2 lacks intrinsic GTPase activity as a monomer but gains catalytic function through heterodimerization with GIMAP7, which provides a catalytic arginine residue to stimulate GTP hydrolysis 1. Structurally, GIMAP2 contains a TRAFAC-class guanine nucleotide-binding domain with a unique amphipathic helix α7, and undergoes conformational changes upon GTP binding that facilitate oligomerization via two distinct interfaces 2. The protein localizes to the endoplasmic reticulum and lipid droplet surfaces, suggesting involvement in lipid metabolism 3. GIMAP2 functions as a nucleotide-regulated scaffold on intracellular membranes and plays critical roles in T-cell death and survival 42. Clinically, GIMAP2 serves as a prognostic marker in various cancers including sarcomas and low-grade gliomas, with reduced expression associated with impaired cell growth and invasion 56. The gene shows differential expression patterns in T-cell lymphomas and has been identified as a susceptibility locus in Behçet's disease 78.