GIMAP6 is a GTPase that plays critical roles in immune system function, autophagy regulation, and vascular homeostasis. The protein complexes with GABARAPL2 and GIMAP7 to regulate GTPase activity and is essential for proper autophagic processes 1. GIMAP6 is required for maintaining peripheral T cell populations, with deficiency leading to 50-70% reduction in CD4+ and CD8+ T cells and disrupted autophagy characterized by increased LC3-II levels and SQSTM1 phosphorylation 2. The protein is induced by IFN-γ and plays a crucial role in antibacterial immunity 1. GIMAP6 deficiency causes a severe primary immunodeficiency syndrome in humans, presenting with infections, lymphoproliferation, autoimmunity, and multiorgan vasculitis 1. Patients show accelerated lymphocyte apoptosis and variable clinical severity, ranging from asymptomatic to recurrent sinopulmonary infections with lymphopenia 3. Importantly, GIMAP6 loss causes inflammatory vasculopathy and accelerated atherosclerosis independent of hyperlipidemia, leading to premature cardiovascular disease and early death 4. The protein demonstrates cell-type-specific expression patterns and serves as a biomarker in various diseases, including lung adenocarcinoma and acute myocardial infarction 56.