GJA10 encodes connexin-62 (Cx62), a gap junction protein that forms hemichannels and gap junctions for intercellular communication 1. In the retina, GJA10 is expressed in the inner and outer plexiform layers 1 and functions as part of the cone-horizontal cell synapse, mediating ephaptic inhibitory feedback through hemichannel-based signaling 2. The protein facilitates both gap junction-mediated and hemichannel-mediated intercellular transport of small molecules 3. Beyond retinal function, GJA10 has been identified in platelets, where connexin-62 regulates agonist-stimulated platelet function and thrombosis independently of other connexins 3. Functionally, GJA10 restores homotypic intercellular transfer and exhibits heterotypic coupling with other connexin isoforms, with unitary conductance of approximately 27 picosiemens 4. Clinically, elevated GJA10 mRNA expression correlates with poor overall survival in gastric cancer patients (P=0.015) 5, and GJA10 was identified among immune-related genes differentially expressed between hot and cold colorectal tumors 6. These findings suggest GJA10 functions in specialized electrical coupling in neural and hematologic tissues, with potential implications for cancer progression.