GKAP1 (G kinase anchoring protein 1) is a scaffolding protein located on chromosome 9 that regulates insulin signaling in adipocytes. Its primary function involves modulating insulin receptor substrate-1 (IRS-1) availability to insulin receptor tyrosine kinase, thereby controlling insulin-dependent IRS-1 phosphorylation 1. GKAP1 binding to IRS-1 is required for insulin-induced glucose transporter 4 (GLUT4) translocation to the cell membrane, a critical step in glucose uptake 1. Mechanistically, GKAP1 associates with IRS-1 protein complexes and facilitates downstream MAPK and PI3K signaling pathway activation 2. GKAP1 is also involved in tumor necrosis factor-α-mediated impairment of insulin signaling, as TNF-α decreases GKAP1 protein levels through cGMP-dependent kinase regulation, contributing to insulin resistance 1. Beyond metabolic function, GKAP1 has disease relevance as a fusion partner in several cancers. GKAP1-NTRK2 fusion proteins have been identified in pediatric gliomas, generating constitutively activated receptor tyrosine kinases responsive to TRK inhibitor therapy 23. GKAP1 is also located within a minimally deleted region in acute myeloid leukemia with del(9q) cytogenetics 4 and has been implicated as a candidate gene in bladder exstrophy-epispadias complex and esophageal squamous cell carcinoma 56.