GLIPR1L2 (GLIPR1 like 2) is a p53 target gene located on chromosome 12 that encodes a secreted protein belonging to the cysteine-rich secretory protein (CRISP), antigen 5, and pathogenesis-related 1 (CAP) superfamily 1. The gene exists in five differentially spliced isoforms and is expressed across multiple tissue types including prostate and bladder 1. GLIPR1L2 is involved in innate immunity and tumor-suppressor/pro-oncogenic mechanisms 2. Mechanistically, CAP domain-containing proteins like GLIPR1L2 are hypothesized to promote cell-cell adhesion and have potential roles in carcinogenesis and immune regulation 3. Clinically, GLIPR1L2 shows relevance to multiple diseases. Blood DNA methylation differences in GLIPR1L2 associate with variation in forced vital capacity (FVC) in middle-aged monozygotic twins (p = 7.14 × 10⁻⁸), suggesting epigenetic regulation of this gene influences lung function 2. Genetic analysis identified GLIPR1L2 as a causal gene in hypopituitarism pathogenesis through summary data-based Mendelian randomization, indicating it may contribute to pituitary endocrine dysfunction 4. These findings suggest GLIPR1L2 represents a potential therapeutic target for diseases involving immune dysregulation and endocrine dysfunction.