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GeneE
2 sources retrieved Β· Most recent: April 2026 Β· Index updated 15 days ago
β“˜GeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
GOLGA1
golgin A1
Chromosome 9 Β· 9q33.3
NCBI Gene: 2800Ensembl: ENSG00000136935.15HGNC: HGNC:4424UniProt: Q92805
41PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
trans-Golgi networktransepithelial transportGolgi apparatusmolecular carrier activityChest painPainbreast cancercancer
✦AI Summary

Based on limited published evidence, GOLGA1 (golgin A1) is a Golgi apparatus protein with molecular carrier activity that plays important roles in protein trafficking and transport. UniProt annotations indicate it functions in poxvirus morphogenesis by translocating to viral factories to transport membrane fragments and associated proteins to virion assembly sites. GOLGA1 is involved in trans-Golgi network organization and transepithelial transport. Recent evidence suggests GOLGA1 dysregulation in gastroenterological cancers, where it associates with poor patient survival and increased invasiveness through altered protein trafficking 1. GOLGA1 also demonstrates stable expression across diverse tissues and cell types, making it suitable as a housekeeping gene for quantitative studies 2.

Sources cited
1
GOLGA1 plays essential role in protein trafficking within Golgi apparatus and is associated with poor survival rates and increased invasiveness in gastroenterological cancers
PMID: 37508488
2
GOLGA1 shows stable expression across various tissues and disease states, qualifying as a reliable housekeeping gene for normalization in RNA-based techniques
PMID: 17394773
⚠Limited data available β€” This gene has 2 indexed publications. Summary and analysis may be incomplete.
Disease Associationsβ“˜20
Chest painOpen Targets
0.31Weak
PainOpen Targets
0.30Weak
breast cancerOpen Targets
0.09Suggestive
cancerOpen Targets
0.09Suggestive
neoplasmOpen Targets
0.08Suggestive
lymphatic system diseaseOpen Targets
0.07Suggestive
benign adult familial myoclonic epilepsyOpen Targets
0.06Suggestive
triple-negative breast cancerOpen Targets
0.05Suggestive
Fuchs endothelial corneal dystrophyOpen Targets
0.05Suggestive
Familial ocular anterior segment mesenchymal dysgenesisOpen Targets
0.05Suggestive
Cataract-microcornea syndromeOpen Targets
0.05Suggestive
dystonia 27Open Targets
0.05Suggestive
essential tremorOpen Targets
0.05Suggestive
Cochleosaccular degeneration - cataractOpen Targets
0.04Suggestive
cochleosaccular degeneration-cataract syndromeOpen Targets
0.04Suggestive
Young adult-onset ParkinsonismOpen Targets
0.04Suggestive
X-linked parkinsonism-spasticity syndromeOpen Targets
0.04Suggestive
Spastic paraparesis - deafnessOpen Targets
0.04Suggestive
spastic paraparesis-deafness syndromeOpen Targets
0.04Suggestive
Primary dystonia, DYT13 typeOpen Targets
0.04Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
STX6Protein interaction100%VTI1AProtein interaction100%STX16Protein interaction100%GOLGB1Protein interaction92%TGOLN2Protein interaction91%COG3Protein interaction89%
Tissue Expression6 tissues
Liver
100%
Heart
86%
Lung
75%
Ovary
70%
Brain
47%
Bone Marrow
43%
Gene Interaction Network
Click a node to explore
GOLGA1STX6VTI1ASTX16GOLGB1TGOLN2COG3
PROTEIN STRUCTURE
Preparing viewer…
AlphaFoldAI-predicted Β· UniProt Q92805
View on AlphaFold β†—
Constraintβ“˜
LOEUFβ“˜
0.69LoF Tolerant
pLIβ“˜
0.00Tolerant
Observed/Expected LoF0.49 [0.36–0.69]
RankingsWhere GOLGA1 stands among ~20K protein-coding genes
  • #10,015of 20,598
    Most Researched41
  • #5,169of 17,882
    Most Constrained (LOEUF)0.69
Genes detectedGOLGA1
Sources retrieved2 papers
Response timeβ€”
πŸ“„ Sources
2
1
Golgi Apparatus Target Proteins in Gastroenterological Cancers: A Comprehensive Review of GOLPH3 and GOLGA Proteins.
PMID: 37508488
Cells Β· 2023
1.00
2
Identification of novel universal housekeeping genes by statistical analysis of microarray data.
PMID: 17394773
J Biochem Mol Biol Β· 2007
0.50