GOLGA7 (golgin A7) is an accessory protein of the ZDHHC palmitoyltransferase complex that plays a critical role in protein S-acylation and membrane trafficking. GOLGA7 forms a catalytically active complex with ZDHHC5 palmitoyltransferase, which is essential for the palmitoylation and proper plasma membrane localization of RAS proteins, particularly NRAS and HRAS 12. This complex localizes to the plasma membrane and is mutually stabilizing between the two proteins 3. The GOLGA7-ZDHHC5 complex regulates protein trafficking from the Golgi apparatus to the plasma membrane and is involved in retrograde protein transport 3. Loss of GOLGA7 disrupts NRAS plasma membrane localization without affecting palmitoylation levels, effectively suppressing oncogenic NRAS-driven leukemogenesis in mouse models 1. Importantly, while GOLGA7 knockout is embryonically lethal, it is dispensable for normal adult hematopoiesis and shows no detectable toxicity when deleted in adult mice, making it a promising therapeutic target for NRAS-driven cancers 1. The protein also plays roles in viral entry, as demonstrated with SARS-CoV-2, and in regulating cell death pathways 43.