Based on limited published evidence, GPBP1L1 is a possible transcription factor with DNA-binding and protein-binding capabilities localized to the nucleus, where it may regulate DNA-templated transcription. The gene was identified as a potential cardiac-relevant locus in a study of stress cardiomyopathy patients, where copy number variants in GPBP1L1 were observed in individuals with earthquake-induced takotsubo syndrome 1. However, functional characterization remains incomplete.