GPHRB — golgi pH regulator B

5 sources retrieved · Most recent: April 2026 · Index updated 5 months ago

42PubMed Papers

#9,901 · top 51% of 19K genes

20Diseases

top 56%

0Drugs

0Pathogenic Variants

Ion ChannelTransporterSwiss-Prot Reviewed

hearing loss, autosomal recessivedeafnessautosomal dominant nonsyndromic hearing lossUsher syndrome type 1

AI Summary

AI summary not yet available. Showing NCBI Gene summary.

golgi pH regulator B

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.

Disease Associations20

hearing loss, autosomal recessiveOpen Targets

0.09Suggestive

deafnessOpen Targets

0.09Suggestive

autosomal dominant nonsyndromic hearing lossOpen Targets

0.09Suggestive

Usher syndromeOpen Targets

0.07Suggestive

Usher syndrome type 1Open Targets

0.07Suggestive

autosomal dominant nonsyndromic hearing loss 2AOpen Targets

0.06Suggestive

auditory neuropathy, autosomal dominant 3Open Targets

0.06Suggestive

Meniere diseaseOpen Targets

0.06Suggestive

auriculocondylar syndromeOpen Targets

0.06Suggestive

question mark ears, isolatedOpen Targets

0.06Suggestive

X-linked nonsyndromic hearing lossOpen Targets

0.06Suggestive

autosomal dominant nonsyndromic hearing loss 17Open Targets

0.06Suggestive

autosomal dominant nonsyndromic hearing loss 7Open Targets

0.06Suggestive

autosomal recessive nonsyndromic hearing loss 102Open Targets

0.06Suggestive

deafness, aminoglycoside-inducedOpen Targets

0.06Suggestive

Mitochondrial non-syndromic sensorineural deafness with susceptibility to aminoglycoside exposureOpen Targets

0.06Suggestive

autosomal recessive nonsyndromic hearing loss 86Open Targets

0.06Suggestive

hearing loss, autosomal dominant 88Open Targets

0.06Suggestive

hearing loss, autosomal dominant 89Open Targets

0.06Suggestive

Unilateral deafnessOpen Targets

0.06Suggestive

Pathogenic Variants

No pathogenic variants reported on ClinVar for this gene.

Related Genes

No related genes found for this gene.

Tissue Expression6 tissues

Liver

100%

Ovary

52%

Lung

37%

Bone Marrow

33%

Brain

30%

Heart

16%

Gene Interaction Network

No interaction data available for this gene.

StructureAlphaFold

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AlphaFoldAI-predicted · UniProt P0CG08

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ConstraintgnomAD v4.1

LOEUFⓘ

0.85LoF Tolerant

pLIⓘ

0.05Tolerant

Observed/Expected LoF0.50 [0.31–0.85]

Rankings2 dim

Where GPHRB stands among ~20K protein-coding genes

#9,878of 20,598
Most Researched42
#7,347of 17,882
Most Constrained (LOEUF)0.85