GPR141 is an orphan G protein-coupled receptor belonging to the rhodopsin-like GPCR superfamily, predominantly expressed in bone marrow and cancer cells 1. Phylogenetic analysis suggests GPR141 may bind N-arachidonylglycine, though its cognate ligand remains unconfirmed 2. GPR141 functions as a membrane-localized signaling protein with roles in multiple disease contexts. In cancer, GPR141 overexpression drives proliferation and metastasis through epithelial-mesenchymal transition and dysregulation of the p-mTOR/p53 signaling axis, with Cullin1-mediated p53 degradation playing a central mechanistic role 3. Pan-cancer analysis reveals GPR141 involvement in immune-related pathways and correlation with poor prognosis across multiple tumor types 4. Beyond cancer, GPR141 associates with periodontitis susceptibility, particularly in smokers 5, and demonstrates dysregulation in Fuchs' endothelial corneal dystrophy progression 6. Additionally, GPR141 shows genetic interaction with Ras/MAPK pathway genes in autism spectrum disorders through epistatic mechanisms 7. Emerging evidence suggests GPR141 participates in ACE2-associated protein networks relevant to COVID-19 pathologies 8. These findings position GPR141 as a potential therapeutic target across multiple disease domains, though its precise ligand identity and complete molecular mechanisms require further characterization.