GPR32 is a G-protein coupled receptor that serves as a key mediator of inflammation resolution by binding specialized pro-resolving mediators, particularly resolvin D1 (RvD1) 1. The receptor transduces anti-inflammatory and pro-resolving signals through multiple intracellular pathways, including calcium mobilization and enhanced phagocytic activity 2. GPR32 is expressed in various cell types including macrophages, oral epithelial cells, and vascular tissues, where it promotes tissue healing and homeostasis 23. Functionally, GPR32 activation enhances macrophage phagocytosis, reduces pro-inflammatory cytokine production, and facilitates clearance of cellular debris during inflammation resolution 1. The receptor plays a protective role in atherosclerosis, as GPR32 expression is reduced in human atherosclerotic lesions, and experimental overexpression reduces lesion area and necrosis 14. GPR32 also modulates periodontal tissue repair by promoting wound healing and proliferation in periodontal ligament fibroblasts 5. Additionally, the receptor contributes to vascular function by reducing coronary artery contractions induced by pro-inflammatory mediators 3. GPR32 represents a therapeutic target for chr19 inflammatory diseases, particularly atherosclerosis and periodontal disease, through its role in promoting active resolution of inflammation.