GTF2A2 (general transcription factor IIA subunit 2) encodes the gamma subunit of TFIIA, a core component of RNA polymerase II transcription machinery. GTF2A2 functions as part of the preinitiation complex, where it works with TBP to facilitate transcriptional activation and positive regulation of RNA polymerase II-dependent transcription initiation 1. The protein exhibits homodimerization and heterodimerization activities and directly associates with TBP-class proteins and other general transcription factors during assembly of the transcription initiation apparatus at promoters. Differential GTF2A2 expression has been identified as a potential biomarker in osteosarcoma, where it shows altered expression levels compared to normal bone tissue 2. In multiple myeloma, GTF2A2 is implicated in imbalanced Th17-like cell differentiation through involvement in IL2-STAT5 pathways 3. Additionally, GTF2A2 appears dysregulated in myeloproliferative neoplasms as a STAT5-p53 target gene 4, with abnormal expression detected in MPN patient platelets. Notably, GTF2A2 is identified as a target of altered autoimmune responses in rheumatoid arthritis, with anti-GTF2A2 autoantibodies present in both ACPA-positive and ACPA-negative RA patients 5, suggesting potential immunological significance beyond its transcriptional regulatory role.