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0 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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H2AC8
H2A clustered histone 8
Chromosome 6 · 6p22.2
NCBI Gene: 3012Ensembl: ENSG00000277075.4HGNC: HGNC:4724UniProt: P04908
74PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
FUNCTIONAL ROLE
Hub Gene
DATA QUALITY
✓ Swiss-Prot Reviewed
viral diseaseinfectious diseasebreast carcinomadengue disease
✦AI Summary

AI summary not yet available. Showing NCBI Gene summary.

H2A clustered histone 8

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsⓘ20
viral diseaseOpen Targets
0.50Moderate
infectious diseaseOpen Targets
0.50Moderate
breast carcinomaOpen Targets
0.39Weak
dengue diseaseOpen Targets
0.39Weak
cancerOpen Targets
0.37Weak
melanomaOpen Targets
0.37Weak
infectionOpen Targets
0.07Suggestive
actinic keratosisOpen Targets
0.05Suggestive
sebaceous of Jadassohn nevusOpen Targets
0.05Suggestive
squamous cell carcinomaOpen Targets
0.04Suggestive
neoplasmOpen Targets
0.03Suggestive
systemic lupus erythematosusOpen Targets
0.02Suggestive
LipedemaOpen Targets
0.02Suggestive
experimental autoimmune encephalomyelitisOpen Targets
0.01Suggestive
goutOpen Targets
0.01Suggestive
triple-negative breast cancerOpen Targets
0.01Suggestive
ovarian cancerOpen Targets
0.01Suggestive
chronic lymphocytic leukemiaOpen Targets
0.01Suggestive
breast cancerOpen Targets
0.01Suggestive
rheumatoid arthritisOpen Targets
0.01Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
BARD1Protein interaction100%CENPAProtein interaction100%CHD4Protein interaction100%DDB2Protein interaction100%EZH2Protein interaction100%H1-0Protein interaction100%
Tissue Expression6 tissues
Bone Marrow
100%
Brain
0%
Heart
0%
Liver
0%
Ovary
0%
Lung
0%
Gene Interaction Network
Click a node to explore
H2AC8BARD1CENPACHD4DDB2EZH2H1-0
PROTEIN STRUCTURE
Preparing viewer…
PDB7VZ4 · 1.89 Å · EM
View on RCSB ↗
Constraintⓘ
LOEUFⓘ
1.85LoF Tolerant
pLIⓘ
0.00Tolerant
Observed/Expected LoF1.18 [0.68–1.85]
RankingsWhere H2AC8 stands among ~20K protein-coding genes
  • #6,398of 20,598
    Most Researched74
  • #16,846of 17,882
    Most Constrained (LOEUF)1.85
Genes detectedH2AC8
Sources retrieved0 papers
Response time—