Based on limited published evidence, H2BC8 is a histone H2B variant clustered on chromosome 6. H2BC8's primary function as a histone protein involves DNA packaging and chr6 structure. Recent bioinformatics analysis identified H2BC8 as one of eleven hub genes associated with continuous positive airway pressure (CPAP) treatment response in obstructive sleep apnea patients, where it was incorporated into a predictive model (AUC 0.92) for therapeutic efficacy 1. The gene's role in OSA treatment response may relate to immune cell modulation, particularly monocyte infiltration patterns.