Based on limited published evidence, H3C6 (H3 clustered histone 6) is a histone protein involved in chr6 structure. H3C6 was identified as a potential candidate gene associated with spontaneous abortion, found within copy number variants enriched for genes related to chr6 structural components 1. Additionally, a CpG probe (cg24440941) within H3C6 showed significant interaction with maternal methylation and gestational diabetes mellitus status in an epigenome-wide association study 2. These findings suggest H3C6 may play a role in embryonic development and metabolic regulation, though functional characterization remains limited.