Based on limited published evidence, H3C8 (H3 clustered histone 8) is a histone gene located on chromosome 6. H3C8 is part of the histone protein family that constitutes structural chr6 components. Recent studies have identified hotspot mutations in H3C8 resulting in H3K27M alterations in canine diffuse large B-cell lymphoma, where such mutations were associated with altered progression-free survival 1. H3C8 has also been identified as a potential candidate gene in copy number variant analyses related to spontaneous abortion 2. The gene's primary function relates to chr6 structure and epigenetic regulation.