H4C12 — H4 clustered histone 12

5 sources retrieved · Most recent: April 2026 · Index updated 3 months ago

124PubMed Papers

#3,795 · top 20% of 19K genes

20Diseases

top 35%

0Drugs

0Pathogenic Variants

Hub GeneSwiss-Prot Reviewed

infectious diseaseviral diseaseTessadori-Van Haaften neurodevelopmental syndrome 3breast carcinoma

AI Summary

AI summary not yet available. Showing NCBI Gene summary.

H4 clustered histone 12

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.

Disease Associations20

infectious diseaseOpen Targets

0.50Moderate

viral diseaseOpen Targets

0.50Moderate

Tessadori-Van Haaften neurodevelopmental syndrome 3Open Targets

0.46Moderate

breast carcinomaOpen Targets

0.39Weak

cancerOpen Targets

0.38Weak

melanomaOpen Targets

0.37Weak

dengue diseaseOpen Targets

0.37Weak

posterior cortical atrophyOpen Targets

0.08Suggestive

breast cancerOpen Targets

0.06Suggestive

actinic keratosisOpen Targets

0.05Suggestive

sebaceous of Jadassohn nevusOpen Targets

0.05Suggestive

squamous cell carcinomaOpen Targets

0.05Suggestive

neoplasmOpen Targets

0.04Suggestive

ataxia telangiectasiaOpen Targets

0.03Suggestive

acute respiratory distress syndromeOpen Targets

0.03Suggestive

malignant hyperthermia, susceptibility to, 1Open Targets

0.03Suggestive

cerebral creatine deficiency syndromeOpen Targets

0.03Suggestive

lung cancerOpen Targets

0.02Suggestive

Ovarian EndometriosisOpen Targets

0.02Suggestive

ulcerative colitisOpen Targets

0.02Suggestive

Pathogenic Variants

No pathogenic variants reported on ClinVar for this gene.

Tissue Expression6 tissues

Bone Marrow

100%

Brain

41%

Lung

Heart

Ovary

Liver

Gene Interaction Network6 neighbors

Click a node to explore

StructureAlphaFold

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AlphaFoldAI-predicted · UniProt P62805

View on AlphaFold

Rankings1 dim

Where H4C12 stands among ~20K protein-coding genes

#3,794of 20,598
Most Researched124 · top quartile

Meta

Genes detectedH4C12

Sources retrieved5 papers

Response time—

Sources5

Three proteins define a class of human histone deacetylases related to yeast Hda1p.

PMID: 10220385

Proc Natl Acad Sci U S A · 1999

0.95

The integrated activities of IRF-2 (HiNF-M), CDP/cut (HiNF-D) and H4TF-2 (HiNF-P) regulate transcription of a cell cycle controlled human histone H4 gene: mechanistic differences between distinct H4 genes.

PMID: 9540062

Mol Biol Rep · 1998

0.95

Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter.

PMID: 9566873

Mol Cell Biol · 1998

0.95

The human histone gene cluster at the D6S105 locus.

PMID: 9439656

Hum Genet · 1997

0.95

Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene.

PMID: 3035717

Science · 1987

0.95

View all 124 papers on PubMed →

Loading gene record…

5 sources retrieved · Most recent: April 2026 · Index updated 3 months ago

124PubMed Papers

#3,795 · top 20% of 19K genes

20Diseases

top 35%

0Drugs

0Pathogenic Variants

Hub GeneSwiss-Prot Reviewed

infectious diseaseviral diseaseTessadori-Van Haaften neurodevelopmental syndrome 3breast carcinoma

AI Summary

AI summary not yet available. Showing NCBI Gene summary.

H4 clustered histone 12

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.

Disease Associations20

infectious diseaseOpen Targets

0.50Moderate

viral diseaseOpen Targets

0.50Moderate

Tessadori-Van Haaften neurodevelopmental syndrome 3Open Targets

0.46Moderate

breast carcinomaOpen Targets

0.39Weak

cancerOpen Targets

0.38Weak

melanomaOpen Targets

0.37Weak

dengue diseaseOpen Targets

0.37Weak

posterior cortical atrophyOpen Targets

0.08Suggestive

breast cancerOpen Targets

0.06Suggestive

actinic keratosisOpen Targets

0.05Suggestive

sebaceous of Jadassohn nevusOpen Targets

0.05Suggestive

squamous cell carcinomaOpen Targets

0.05Suggestive

neoplasmOpen Targets

0.04Suggestive

ataxia telangiectasiaOpen Targets

0.03Suggestive

acute respiratory distress syndromeOpen Targets

0.03Suggestive

malignant hyperthermia, susceptibility to, 1Open Targets

0.03Suggestive

cerebral creatine deficiency syndromeOpen Targets

0.03Suggestive

lung cancerOpen Targets

0.02Suggestive

Ovarian EndometriosisOpen Targets

0.02Suggestive

ulcerative colitisOpen Targets

0.02Suggestive

Pathogenic Variants

No pathogenic variants reported on ClinVar for this gene.

Tissue Expression6 tissues

Bone Marrow

100%

Brain

41%

Lung

Heart

Ovary

Liver

Gene Interaction Network6 neighbors

Click a node to explore

StructureAlphaFold

Preparing viewer…

AlphaFoldAI-predicted · UniProt P62805

View on AlphaFold

Rankings1 dim

Where H4C12 stands among ~20K protein-coding genes

#3,794of 20,598
Most Researched124 · top quartile