HomeAboutRankingsData Sources
© 2026 GeneE
🧬
GeneE
1 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
ⓘGeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
H4C13
H4 clustered histone 13
Chromosome 6 · 6p22.1
NCBI Gene: 8368Ensembl: ENSG00000158406.6HGNC: HGNC:20510UniProt: B2R4R0
128PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
FUNCTIONAL ROLE
Hub Gene
DATA QUALITY
✓ Swiss-Prot Reviewed
infectious diseaseviral diseaseTessadori-Van Haaften neurodevelopmental syndrome 3breast carcinoma
✦AI Summary

Based on limited published evidence, H4C13 (H4 clustered histone 13) is a histone protein encoded on chromosome 6. The gene's specific molecular function remains largely undocumented in structured databases. However, H4C13 has been identified as a shared transcriptome-wide association signal across multiple psychiatric disorders (bipolar disorder, major depressive disorder, posttraumatic stress disorder, and schizophrenia) in developing brain tissue 1. The gene appears implicated in pathways related to neurotransmitter regulation and neural development, though mechanistic details require further investigation.

Sources cited
1
H4C13 identified as a shared TWAS signal across multiple psychiatric disorders in developing brain, associated with neurotransmitter regulation and neural development pathways
PMID: 41461652
⚠Limited data available — This gene has 1 indexed publication. Summary and analysis may be incomplete.
Disease Associationsⓘ20
infectious diseaseOpen Targets
0.50Moderate
viral diseaseOpen Targets
0.50Moderate
Tessadori-Van Haaften neurodevelopmental syndrome 3Open Targets
0.46Moderate
breast carcinomaOpen Targets
0.39Weak
cancerOpen Targets
0.38Weak
melanomaOpen Targets
0.37Weak
dengue diseaseOpen Targets
0.37Weak
posterior cortical atrophyOpen Targets
0.08Suggestive
sebaceous of Jadassohn nevusOpen Targets
0.07Suggestive
actinic keratosisOpen Targets
0.07Suggestive
squamous cell carcinomaOpen Targets
0.06Suggestive
breast cancerOpen Targets
0.06Suggestive
neoplasmOpen Targets
0.04Suggestive
acute respiratory distress syndromeOpen Targets
0.03Suggestive
malignant hyperthermia, susceptibility to, 1Open Targets
0.03Suggestive
cerebral creatine deficiency syndromeOpen Targets
0.03Suggestive
lung cancerOpen Targets
0.02Suggestive
Ovarian EndometriosisOpen Targets
0.02Suggestive
systemic lupus erythematosusOpen Targets
0.02Suggestive
ulcerative colitisOpen Targets
0.02Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
H3-3BProtein interaction100%H3C12Protein interaction100%H2BC12Protein interaction100%H4C6Protein interaction100%H2BC11Protein interaction99%H2AC21Protein interaction98%
Tissue Expression6 tissues
Lung
100%
Brain
63%
Liver
50%
Ovary
0%
Heart
0%
Bone Marrow
0%
Gene Interaction Network
Click a node to explore
H4C13H3-3BH3C12H2BC12H4C6H2BC11H2AC21
PROTEIN STRUCTURE
Preparing viewer…
AlphaFoldAI-predicted · UniProt P62805
View on AlphaFold ↗
RankingsWhere H4C13 stands among ~20K protein-coding genes
  • #3,653of 20,598
    Most Researched128 · top quartile
Genes detectedH4C13
Sources retrieved1 papers
Response time—
📄 Sources
1
1
Leveraging genomic and transcriptomic data of diverse ancestry to uncover mechanisms of psychiatric risk in the adult and developing brain.
PMID: 41461652
Nat Commun · 2025
1.00