HLX is a homeobox transcription factor that plays critical roles in development and cellular regulation. During embryogenesis, HLX is essential for normal intestinal and hepatic development, being expressed in the mesenchyme of developing digestive organs 1. The gene shows remarkable evolutionary conservation across vertebrates, with identical gene organization and highly conserved protein sequences from fish to mammals 1. In placental development, HLX regulates trophoblast cell migration through the HGF/c-met signaling pathway, with decreased HLX expression associated with fetal growth restriction 23. HLX functions as a downstream effector of hepatocyte growth factor, controlling cell migration but not invasion in trophoblast cells 2. Recent studies reveal HLX's oncogenic role in group 3 medulloepithelioma, where it activates oncogenes including MYC, TBX2, and LIN9 through direct promoter binding 4. The gene participates in a therapeutically targetable positive feedback loop with lnc-HLX-2-7 and MYC that promotes tumor progression 4. Genome-wide association studies have also identified HLX variants associated with preserved ratio impaired spirometry, suggesting broader roles in respiratory function 5. Additionally, HLX has been implicated in inflammatory pathways connecting psoriasis and Alzheimer's disease 6.