HNRNPCL1 (heterogeneous nuclear ribonucleoprotein C like 1) is an RNA-binding protein located on chromosome 1 that may play a role in nucleosome assembly by neutralizing basic proteins such as core hnRNPs. The protein demonstrates RNA binding capacity and localizes to the nucleus, where it participates in protein-protein interactions 1. HNRNPCL1 has emerged as a candidate gene in disease contexts. In pulmonary lymphoepithelioma-like carcinoma (pLELC), HNRNPCL1 was identified as one of seven N6-methyladenosine (m6A)-related differentially expressed genes with potential diagnostic significance, as m6A dysregulation contributes to cancer development 2. Additionally, damaging variants in HNRNPCL1 were detected in patients with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome, a rare developmental disorder characterized by Müllerian duct aplasia, suggesting a potential role in reproductive system development 3. Clinically, HNRNPCL1 shows promise as a biomarker candidate in cancer diagnostics. Its altered expression patterns in disease states suggest potential applications in developing diagnostic tools and understanding cancer progression mechanisms, though further validation is required before clinical implementation.