Based on limited published evidence, HNRNPCL2 (also known as RALY) is an RNA-binding protein with predicted roles in nucleosome assembly through neutralization of basic core hnRNPs. It binds RNA and proteins, localizing to the nucleus. HNRNPCL2 functions as a regulatory component of the Drosha complex, promoting miRNA processing 1. In colorectal cancer, it enhances processing of specific miRNAs (miR-483, miR-676, miR-877) that downregulate mitochondrial metabolism genes, associating with poor prognosis 1. HNRNPCL2 is also detected in microvesicles from aggressive stem-like medulloblastoma cells, suggesting potential biomarker utility 2.