HTATIP2 (HIV-1 Tat interactive protein 2) functions as a tumor suppressor gene with pleiotropic roles in cell regulation and disease pathogenesis. The protein represses translation by preventing reactivation of elongation factor eEF1A and may inhibit nuclear import by competing with nuclear transport receptors for binding 1. Additionally, HTATIP2 acts as a redox sensor in cellular oxidative stress surveillance 2. HTATIP2 expression is frequently downregulated in multiple cancer types through promoter methylation. In glioma, HTATIP2 loss occurs in ~60% of primary tumors and is associated with poor prognosis; restoration via demethylating agents inhibits proliferation 3. In cholangiocarcinoma, high HTATIP2 methylation correlates with longer overall survival 4. Conversely, HTATIP2 overexpression in gastric cancer associates with favorable prognosis, reduced lymph node metastasis, and decreased epithelial-mesenchymal transition through Snail/Slug downregulation 5. Beyond cancer, HTATIP2 suppresses angiogenesis and arteriogenesis; elevated HTATIP2 in monocytes from limb ischemia patients impairs neovascularization, which is rescued by HTATIP2 silencing 6. In hepatocellular carcinoma, HTATIP2 expression combined with microvessel density predicts differential survival outcomes depending on sorafenib treatment 7. HTATIP2 involvement in bronchopulmonary dysplasia suggests broader roles in developmental pathways 8.