IDNK (IDNK gluconokinase) is a gluconokinase enzyme that catalyzes the phosphorylation of gluconate to generate 6-phosphogluconate 1. The reaction follows a ternary complex mechanism with ATP binding preceding substrate phosphorylation, and is subject to product inhibition by gluconate 1. In immune contexts, IDNK expression is modulated in CD8 effector T cells and shows altered expression patterns in disease states. Notably, IDNK expression changes in CD8 effector T cells from Graves' ophthalmopathy (GO) patients correlate with disease phenotypes, including enhanced T cell chemotaxis and exhaustion, with these cells capable of infiltrating orbital tissues and upregulating fibrosis-related pathways 2. IDNK was also identified in gene expression profiling of induced decidual NK (idNK) cells, which are generated through ex vivo manipulation of peripheral NK cells and demonstrate improved placental perfusion when transplanted into pregnant mice 3. While IDNK's metabolic function in gluconate metabolism is established, its specific role in immune cell differentiation and function requires further investigation. The gene's dysregulation in autoimmune contexts and involvement in immune cell populations suggests potential relevance to immune homeostasis and disease pathogenesis.