IL11RA (interleukin 11 receptor subunit alpha) serves as the primary receptor subunit for IL-11 signaling, playing crucial roles in both physiological and pathological processes. The receptor functions through classical membrane-bound signaling and trans-signaling mechanisms, where soluble IL11RA acts as an agonist to form IL11:sIL11RA complexes that bind to IL6ST/gp130 on cell surfaces 12. IL11RA mediates diverse cellular responses including fibroblast activation and cardiovascular fibrosis through ERK-dependent autocrine signaling pathways 3. The receptor is critical in hepatocyte lipotoxicity, where IL11RA-mediated signaling drives NOX4-derived ROS production, ERK/JNK activation, and hepatocyte death, contributing to the transition from NAFLD to NASH 4. Clinical significance includes severe cardiac toxicity, as IL11 injection causes acute left ventricular dysfunction through direct IL11RA/JAK/STAT3 activation in cardiomyocytes 5. In liver disease, elevated IL-11 serum levels correlate with disease severity and serve as independent prognostic factors for transplant-free survival 6. Therapeutically, IL11RA represents a promising target, as blocking IL-11 signaling prevents, halts, or reverses fibrosis development across multiple organ systems 7. The receptor also shows prognostic significance in lung adenocarcinoma, where reduced expression correlates with poor survival outcomes 8.