Based on limited published evidence, INSYN2A is a scaffold protein component of inhibitory synapses that regulates postsynaptic density organization and function. UniProt annotations indicate it mediates protein binding and contributes to inhibitory postsynaptic potentials, which dampen neuronal activity and are essential for central nervous system information processing. Recent clinical findings suggest INSYN2A involvement in cognitive phenotypes associated with 10q26 microdeletion syndrome, though its specific mechanistic role in cognition requires further investigation 1.