INTS4 (integrator complex subunit 4) is a scaffolding component of the Integrator complex, a multiprotein assembly essential for transcriptional regulation and RNA processing. INTS4 functions as a helical repeat protein that stabilizes the catalytic core of Integrator by linking INTS9 and INTS11 through multiple interdependent interfaces 1, forming a ternary complex responsible for endonucleolytic activity 2. The Integrator complex terminates RNA polymerase II transcription in promoter-proximal regions through three mechanisms: dephosphorylating Pol II's C-terminal domain, degrading nascent RNA via endonuclease activity, and promoting Pol II release from DNA [UniProt citations]. INTS4 is critical for 3'-end processing of non-coding RNAs including snRNAs, enhancer RNAs, and lncRNAs 2. Additionally, proper INTS4 function requires inositol hexakisphosphate (IP6) as a cofactor that stabilizes the cleavage module conformation; assembly defects involving INTS4 are associated with neurodevelopmental disorders 3. INTS4 depletion impairs snRNA maturation and disrupts Cajal body integrity, demonstrating its importance for nuclear body homeostasis 4. Functionally, INTS4 interacts with proteins regulating neuroplasticity and apoptosis 5, suggesting roles beyond transcriptional regulation. Recent immunoproteomic studies identified INTS4 as an immunogenic antigen in MEN1-related neuroendocrine tumors 6, indicating potential clinical significance.