IQCK (IQ motif containing K) is a novel Alzheimer's disease risk gene recently identified through large-scale genetic meta-analyses 1. The protein is abundantly expressed in the brain, localized to both neuronal nuclei and cytoplasm, with highest expression in the brainstem, cerebellum, and cortex 2. IQCK is expressed in neurons, astrocytes, and oligodendrocytes but not microglia 2. Mechanistically, IQCK protein levels are markedly elevated in Alzheimer's disease brains (approximately 2-fold increase) 2 and in disease-model mice, with increases up to 1246% in certain brain regions 3. IQCK is localized to amyloid plaques, suggesting involvement in Aβ generation or plaque deposition 2. In transcriptomic analyses, IQCK expression correlates with amyloid-β and phospho-tau pathology in astrocytes 4. Beyond Alzheimer's disease, IQCK has been implicated in multiple system atrophy as an over-expressed circular RNA 5, primary open-angle glaucoma as a risk gene 6, and shows differential DNA methylation in immunoglobulin-G4-related disease 7. However, the precise molecular mechanisms by which IQCK increases disease risk remain largely unknown and require further investigation.