IQGAP1 is a multifunctional scaffold protein that plays crucial roles in cellular signaling, membrane integrity, and cancer progression. As a scaffold protein, IQGAP1 assembles multiprotein signaling complexes and serves as a critical node bridging receptor activation to cellular signaling pathways 1. It functions as a scaffold for ERK1/2 MAP kinase cascades, regulating processes including cell adhesion, migration, and proliferation 2. IQGAP1 cooperates with ESCRT systems and ATG9A to maintain plasma membrane integrity, protecting cells from programmed and incidental membrane permeabilization 3. In cancer contexts, IQGAP1 promotes metastasis by regulating β1-integrin expression through ERK/FAK signaling and MRTF/SRF transcriptional pathways, facilitating cancer cell adhesion to endothelial cells under shear stress conditions 4. Additionally, IQGAP1 can promote pathological processes, including endothelial cell pyroptosis in atherosclerosis through mitochondrial damage and cGAS-STING pathway activation 5, and contribute to trastuzumab resistance in gastric cancer by driving microvesicle secretion 6. IQGAP1 also regulates endometrial receptivity, with dysregulation contributing to implantation failure through altered cell polarity and adhesion 7.