ITGB3 (integrin subunit beta 3) is a cell adhesion molecule that mediates integrin-dependent cellular functions across multiple tissues. Structurally, ITGB3 functions as the β3 subunit of αIIbβ3 (fibrinogen receptor) and αvβ3 (vitronectin receptor) integrins, enabling cell-matrix and cell-cell adhesion 1. In trophoblast cells, ITGB3 promotes proliferation, migration, invasion, and adhesion while inhibiting apoptosis 2. Conversely, miRNA-103b-mediated downregulation of ITGB3 promotes apoptosis in stored platelets 3, and ITGB3 knockdown enhances radiosensitivity in osteosarcoma through JNK/c-JUN/RUNX2 pathway activation 4. Clinically, ITGB3 deficiency causes Glanzmann thrombasthenia, characterized by impaired platelet aggregation and mucocutaneous bleeding 1. In preeclampsia, reduced ITGB3 expression correlates with impaired trophoblast function 2. ITGB3 polymorphisms associate with schizophrenia age-at-onset 5 and autism through gene-gene interactions with SLC6A4 6. In focal segmental glomerulosclerosis, TSP-1/ITGB3 signaling mediates renal tubulointerstitial injury, blocked by cyclo-RGDfK 7. In osteosarcoma, ITGB3 promotes cisplatin resistance via MAPK and VEGF signaling pathways 8, positioning it as a therapeutic target.