ITGB5 encodes integrin subunit beta 5, which forms heterodimeric integrin complexes, particularly with ITGAV (alphav), functioning as a cell adhesion receptor involved in extracellular matrix interactions and cellular signaling. The ITGAV/ITGB5 complex serves as a receptor for periostin (POSTN), activating the PI3K/AKT/β-catenin pathway to promote epithelial-mesenchymal transition in pancreatic ductal adenocarcinoma 1. ITGB5 also interacts with GPNMB through direct binding, contributing to vascular fibrosis in glioblastoma 2. Mechanistically, ITGB5 protein levels are regulated through enhanced translation driven by FBXO32-mediated eEF1A1 activation, which subsequently activates focal adhesion kinase (FAK) signaling to promote cancer cell migration and metastasis 3. In hepatocellular carcinoma, ITGB5 forms complexes with EPS15 to prevent EGFR degradation, creating a positive feedback loop with CSNK1A1 that confers sorafenib resistance 4. Additionally, ITGB5 regulates chemotherapy-induced pyroptosis through ASAH2-driven sphingolipid metabolism via Src-STAT3 signaling, contributing to chemoresistance in lung and pancreatic cancers 5. ITGB5 mRNA stability is enhanced by N4-acetylcytidine modifications mediated by NAT10, promoting perineural invasion in pancreatic cancer through FAK-Src pathway activation 6. In intestinal epithelial cells, ITGB5 provides protection against bacterial adhesion and maintains epithelial barrier function 7.