Unable to provide a gene function summary for IVL (involucrin). The provided PubMed abstracts do not contain information about involucrin gene function. All six abstracts discuss intravenous lidocaine (IVL) or intravascular lithotripsy (IVL) in clinical contexts—neither relates to the involucrin protein. One abstract 1 does mention involucrin as a barrier-related molecule in atopic dermatitis, stating that involucrin expression is downregulated by IL-4, IL-13, IL-22, and IL-17A via STAT3/STAT6 pathways, and can be upregulated by aryl hydrocarbon receptor (AHR) ligands and NRF2 activation. However, this single source provides insufficient detail to characterize involucrin's primary function, detailed mechanism of action, comprehensive disease relevance, or clinical significance as required for an adequate gene function summary. Additional peer-reviewed literature specifically focused on involucrin biology would be necessary to complete this analysis.